LymphGen

A precision medicine tool to assign DLBCL types to genetic subtypes.

Paper: "A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications"

George W. Wright, et al. Cancer cell 37.4 (2020): 551-568.

LLMPP-Lymph2CX

A DLBCL cell-of-origin Classifier.
 
To use this tool outside of NIH, you will need login credentials. Please email zana.coulibaly@nih.gov to request a username and password.

SignatureDB

A comprehensive database of gene expression signatures utilized for the molecular characterization and differentiation of genetic subtypes of DLBCL.

Paper: "A Library of Gene Expression Signatures to Illuminate Normal and Pathological Lymphoid Biology"

Arthur L. Shaffer, et al. Immunological reviews 210.1 (2006): 67-8

Bruton's Tyrosine Kinase Inhibitors

Paper: "Response to Bruton's Tyrosine Kinase Inhibitors in Aggressive Lymphomas Linked to Chronic Selective Autophagy."

James D. Phelan, et al. Cancer cell 42.2 (2024): 238-252.

Supplemental data.

IRF4

Paper: "IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma."

Arnold Bolomsky, et al. Cancer Cell 42.7 (2024): 1185-1201.

Supplemental data.

Epigenetic Resistance to BTK Inhibitors

Paper: "Overcoming Acquired Epigenetic Resistance to BTK Inhibitors."

Arthur L. Shaffer, et al. Blood Cancer Discovery. 2021; 2 (6): 630–647. doi: 10.1158/2643-3230. BCD-21-0063

Supplemental data.

Multiprotein Supercomplex Controlling Oncogenic Signalling

Paper: "A multiprotein supercomplex controlling oncogenic signalling in lymphoma."

Phelan, James D., et al. Nature 560.7718 (2018): 387-391.

Supplemental data.

Follicular Lymphoma Predictor

Paper: "Prediction of Survival in Follicular Lymphoma Based on Molecular Features of Tumor-Infiltrating Immune Cells."

S. Dave, et al. New England Journal of Medicine, Vol 351, 2159-2169 Nov 2004.

Supplemental data.

Gene Expression-based Method

Paper: "A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma."

George W. Wright, et al. PNAS, Vol 100, 9991-9996, Aug 2003.

Supplemental data.

Proliferation Gene Expression

Paper: "The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma"

A. Rosenwald, et al. Cancer Cell, Vol 3, 185-197, Feb 2003.

Supplemental data.

Use of Molecular Profiling

Paper: "The Use of Molecular Profiling to Predict Survival after Chemotherapy for Diffuse Large B-Cell Lymphoma"

A. Rosenwald, et al. New England Journal of Medicine, 346:1937-1947 (2002).

Supplemental data.

Phenotype to Mutation

Paper: "Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia"

A. Rosenwald, et al. The Journal of Experimental Medicine, 149:1639-1667 (2001).

Supplemental data.

Distinct types of DLBCL

Paper: "Distinct Types of Diffuse Large B-Cell Lymphoma Identified By Gene Expression Profiling"

A. Alizadeh, et al. Nature 403: 503-511 (2000).

Supplemental data.